• PF also a dual Aurora A and Aurora

  2025-02-07

  

  PF-03814735, also a dual Aurora-A and Aurora-B inhibitor, was administered in a phase I dose escalation study in a 3-weekly Afatinib dimaleate for 5 or 10 consecutive days [69], [70]. To date 25 patients have been included in 7 dose levels (5–100mg/day for 5 days). Using the 5-day schedule the MTD

• br Regulation of V ATPase assembly in response to changes

  2025-02-07

  

  Regulation of V-ATPase assembly in response to changes in amino TP-0903 levels A central regulator of cell growth and metabolism is mTORC1 [38]. mTORC1 integrates signals from nutrient availability and growth factor receptors to control such processes as protein and lipid synthesis and autophagy

• The tumor suppressor function of LOX in normal

  2025-02-07

  

  The tumor-suppressor function of 15-LOX-2 in normal prostate epithelial cells may be explained by the induction of replicative senescence [14,15]. Thus, 15-LOX-2 is overexpressed in age-dependent prostatic hyperplasia, but cell senescence may hinder progression to malignant transformation. Notwithst

• Recent studies have demonstrated significant

  2025-02-07

  

  Recent studies have demonstrated significant cross-talk between XRCC1 (a key player in carboxypeptidase a excision repair (BER) and single strand break repair) and DDR [30], [31], [32]. ATM and DNA-PKcs are known to be involved in the phosphorylation of XRCC1 to promote BER [30], [31]. We have rece

• Regulators of the DDR have therefore become attractive targe

  2025-02-07

  

  Regulators of the DDR have therefore become attractive targets for cancer therapy primarily through two potential approaches. First, to be used as chemo- or radiosensitisers to increase the effectiveness of standard genotoxic treatments and to help prevent or overcome the development of resistance.

• br Experimental section br Acknowledgements br Introduction

  2025-02-07

  

  Experimental section Acknowledgements Introduction DJ-1 is a highly conserved, homodimeric protein that was originally cloned as an oncogene capable of transforming Magnetic beads CUT&RUN in cooperation with activated ras[1]. DJ-1 is over-expressed in multiple tumor types and is positively

• br Future view and implications The selection and spread of

  2025-02-07

  

  Future view and implications The selection and spread of multi(drug)-resistant microorganisms over the last decades has become a major and global public health concern [35]. Two growing threats originating from the fungal kingdom, i.e. Aspergillus fumigatus and Candida auris[36], [37], re-emphasi

• br Brain Angiotensin II receptors The

  2025-02-07

  

  Brain Angiotensin II receptors The information above leaves Angiotensin II receptors as the only RAAS components for which localization, regulation of expression and function in the Mean arterial pressure reducer has been convincingly demonstrated, with the use of quantitative film and emulsion

• Interestingly ZIP expression was decreased in dog testes aft

  2025-02-07

  

  Interestingly, ZIP9 expression was decreased in dog testes after they were implanted with gonadotropin releasing hormone (GnRH) which the authors proposed was due to androgen ablation (Bulldan et al., 2016a). The expression of other members of the ZIP (SLC39A) family has also been shown to be regula

• br MHCI peptide editing N terminal extensions and

  2025-02-07

  

  MHCI peptide editing, N-terminal extensions and the peptide loading complex Conventionally, peptide-MHCI binding is thought to require both amino- and carboxyl-termini for stable interaction (Madden, 1995; Bouvier and Wiley, 1994). Peptides with longer than optimal length (10–13 residues) have be

• Dose Response Studies Against Puromycin Sensitive Aminopepti

  2025-02-07

  

  Dose–Response Studies Against Puromycin–Sensitive Aminopeptidase (PSA). PSA is a ubiquitous metallopeptidase encoded by the NPEPPS gene with subcellular distribution in the cytosol and nucleus [49]. Comprising of a 919 amino survivin (baculoviral IAP repeat-containing protein 5) (21-28) sequence, i

• Acetaminophen N acetyl p aminophenol AAP Fig is a medically

  2025-02-07

  

  Acetaminophen (N-acetyl-p-aminophenol, AAP) (Fig. 1) is a medically important, low cost, readily available and commonly used over the counter analgesic and antipyretic drug [18,19]. Acetaminophen monotherapy is efficient and is safer than Aspirin and Ibuprofen [20]. The efficacy and tolerability in

• AdipoR and AdipoR have been reported to be present

  2025-02-06

  

  AdipoR1 and AdipoR2 have been reported to be present in almost all type of tissues and low phospholipase a2 inhibitor levels have been observed in white adipose tissue (Inukai et al., 2005). These receptors have been observed to become deregulated with the onset of obesity, resulting in a reduced l

• Lipotoxicity is the accumulation of excess lipids

  2025-02-06

  

  Lipotoxicity is the accumulation of excess lipids in non-adipose tissues that leads to cell dysfunction or cell death. It may play an important role in the pathogenesis of diabetes, and contributes to the rate of progression of CKD [7,8]. Emerging evidence indicates that renal lipid dysregulation is

• We have previously reported that interfering with actin asse

  2025-02-06

  

  We have previously reported that interfering with death associated protein kinase assembly dynamics by knocking down cofilin-1 in hMSCs increased polymerized actin that promoted osteoblast cell differentiation through a mechanism of enhancing focal adhesion kinase (FAK), p38 and c-Jun N-terminal ki

14433 records 16/963 page Previous Next First page 上5页 1617181920 下5页 Last page