• In an effort to increase

  2023-11-30

  

  In an effort to increase antioxidant properties of peptides from WP, Le Maux et al. (2016) altered the hydrolysis conditions (pH, enzyme type, reaction time, and temperature). Hydrolysis of WP (81% protein) test samples with papain (EC 3.4.22.2) at a constant pH of 7.0 gave significantly higher ORAC

• br Experimental procedures br Results br Discussion Our biop

  2023-11-29

  

  Experimental procedures Results Discussion Our biophysical and cellular analyses of mutant Aβ1–42 peptides support a role of the N-terminus of Aβ in peptide aggregation and toxicity. We demonstrate that double mutations constructed to humanize the rodent Aβ1–42 sequence result in a signific

• Perhaps the first evidence of AMPKs therapeutic

  2023-11-29

  

  Perhaps the first evidence of AMPKs therapeutic ability in DM1 came from Thomas Cooper’s laboratory where they demonstrated that insulin-independent glucose uptake was unaffected in human DM1 muscle Actinomycin D treated with MET, an AMPK activator and first-line therapy for type 2 diabetes mellitu

• In conclusion our study would seem to indicate

  2023-11-29

  

  In conclusion, our study would seem to indicate that a hydrophilic microenvironment, which is suitable to accommodate highly hydrophilic molecules with steric hindrance such as aldose hemiacetals, allows the enzyme modulation by one of its most important physiopathological substrates. It is difficul

• br Materials and methods br Results br Discussion More

  2023-11-29

  

  Materials and methods Results Discussion More experiments were performed in order to explain the mechanism that is involved in Eribulin death both PC3 and Hep G2 cells using compound 5. Results showed that this compound inhibits cell viability inducing apoptosis in a concentration-dependen

• br Conclusion Our study of late life

  2023-11-29

  

  Conclusion Our study of late-life depression provides evidence of genotype-specific associations between depression and ACE methylation, as well as inverse correlations between ACE methylation and THZ1 Hydrochloride secretion. These findings highlight the potential need to consider methylation l

• br Acknowledgment This study was supported by Japan Society

  2023-11-28

  

  Acknowledgment This study was supported by Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [grant number 15K15031]. Introduction Glioma is the leading malignancy of astrocyte origin in the brain. The most aggressive, invasive, and destructive glioma

• Moreover a multiple regression analysis using the year

  2023-11-28

  

  Moreover, a multiple regression analysis using the 1-year MMSE score as a dependent variable was conducted. The result showed that serum Prednisone levels at admission did not affect the MMSE score 1 year later (β = 0.10, p = 0.639). Discussion In this study, serum Aβ42 levels were significantl

• br Results We set out to identify in

  2023-11-28

  

  Results We set out to identify in an unbiased manner a set of candidate “scaling factors” that might participate in transcription-dependent synaptic scaling up. The ex vivo slice and profiling studies were conducted on HsCt5 mice (described later) at postnatal day (P) 14 to P15, an age at which s

• OCT also is known as POU F plays

  2023-11-28

  

  OCT4 (also is known as POU5F1) plays an important role in embryonic stem cell self-renewal, development and reprogram somatic cell into pluripotent stem cell [[5], [6], [7]]. Recently, many studies also find OCT4 promotes the progression of many tumors. For example, Wnt/β-catenin promotes the expans

• Interestingly hypoxia and an enhanced Warburg effect

  2023-11-28

  

  Interestingly, hypoxia and an enhanced Warburg effect ultimately lead to increased lactate production. The accumulation of lactate results in an acidic tumor microenvironment, which induces local inflammation. Lactate also promotes the polarization of macrophages that express immunosuppressive argin

• br Experimental procedure br Introduction Migraine is

  2023-11-28

  

  Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of

• Kobe0065 The CK catalyzes the reversible conversion of creat

  2023-11-28

  

  The CK catalyzes the reversible conversion of creatine into creatine phosphate using ATP and thereby releasing ADP. The CK isoenzymes, specifically localized in places where there is a demand and production of energy, are linked to a creatine/creatine phosphate shuttle (Wallimann et al., 1998). This

• Mast cells Mast cells are immune cells of the

  2023-11-28

  

  Mast cells. Mast price scd are immune cells of the myeloid lineage and are ubiquitously present in connective tissues [75]. These cells are involved in the modulation of a number of physiological functions, such as vasodilation, angiogenesis, bacterial, and parasite elimination [75]. Moreover, mast

• br Actin at presynapses br

  2023-11-28

  

  Actin at presynapses Conclusion Thanks to the recent discovery of rings, hotspots and trails, axonal TAK-875 is back in the spotlight. These are exiting times for neuronal cell biologists armed with constantly improving labeling and imaging techniques to observe, quantify and perturb these str

14064 records 208/938 page Previous Next First page 上5页 206207208209210 下5页 Last page