• In a mouse model of hyperhomocysteinemia a risk factor for

  2022-04-12

  

  In a mouse model of hyperhomocysteinemia (a risk factor for the development of vascular dysfunction) it has been shown that myoendothelial communication is enhanced due to increased expression of Cx37 and IK1 AZD4547 [], allowing the propagation of endothelial signals to VSMC and thereby decreasing

• It has also been demonstrated that PS

  2022-04-12

  

  It has also been demonstrated that PS1 is ubiquitinated by Caenorhabditis elegans SEL-10 [52], Fbw7 the mammalian homologue of SEL-10 [38], and more recently by tumour necrosis factor Albendazole receptor associated factor 6 (TRAF6), which facilitates Lysine-63 (K63)-linked polyubiquitination of PS

• An advantage of photolabeling with tritiated photoprobes fol

  2022-04-12

  

  An advantage of photolabeling with tritiated photoprobes followed by microsequencing with Edman degradation is the ability to both identify the photolabeled STF 083010 and to quantify photoincorporation which enables assessment of pharmacological specificity and allosteric interactions with other l

• The schematic diagram of the antagonistic

  2022-04-12

  

  The schematic diagram of the antagonistic interactions of Zn2+ and neurosteroids (NSs) at GABA-A receptors is summarized in Fig. 7. Neurosteroids exhibit powerful seizure protective effects against experimental seizures probably through the potentiation of synaptic and extrasynaptic GABA-A receptor-

• At baseline Hdc KO mice have alterations in the

  2022-04-11

  

  At baseline, Hdc-KO mice have alterations in the examined signaling cascades that resemble those seen in WT mice after RAMH challenge. Specifically, INF39 of MSK1 at T581 and of rpS6 ad S235/236 are elevated in dMSNs to a similar extent after saline in KO mice and after RAMH challenge in WT sibling

• Our results demonstrated that most

  2022-04-11

  

  Our results demonstrated that most of the HUA rings incubated with 100 μM TBT do not have the capacity to contract in the presence of 5-HT or exhibit very low contractions in comparison to the control. Only 23.3% of the HUA rings were able to contract. These results seem to indicate that there may b

• Yap and Taz may regulate

  2022-04-11

  

  Yap and Taz may regulate epicardial cell proliferation, EMT, and fate determination via multiple mechanisms. In this study, we provide evidence that Yap/Taz function in part by directly modulating Tbx18 and Wt1 expression. Members of the T-box family of transcription factors regulate a variety of de

• In tumor cells HK II induction

  2022-04-11

  

  In tumor cells HK-II induction is mediated by Akt/mTOR pathway [6], [11]. HK-II dynamically shuttles between the mitochondria and cytoplasm under different metabolic conditions. In cardiomyocytes, Akt enhances HK-II binding to mitochondria, setting the heart at a state resistant to ischemic injury [

• br Hedgehog pathway in embryonic development

  2022-04-11

  

  Hedgehog pathway in embryonic development It is now well established that the Hedgehog pathway solves a role as one of the essential signaling mechanisms for the modulation of cellular growth and differentiation during embryogenesis. Operating through time- and position-dependent mechanisms, this

• Renal disease is characterized by aberrant fibrotic remodeli

  2022-04-11

  

  Renal disease is characterized by aberrant fibrotic remodeling of renal tissue, elevated apoptosis in kidney tissue, and eventual organ failure. In addition, patients with renal disease are more likely to suffer from systemic hypertension due to oxidative damage (reviewed in Ref. [18]). Treatment of

• Enzyme parameters obtained for GC E

  2022-04-11

  

  Enzyme parameters obtained for GC-E variants can further be introduced in kinetic models of phototransduction using computational approaches. A similar approach has been successfully applied in the investigation of disease causing mutations of GCAP1 to simulate rod and cone photoresponses under dise

• For some agonists these stable GPR responses

  2022-04-11

  

  For some agonists, these stable GPR119 responses were resistant to washing. Thus, sustained activation could continue, for at least a number of hours, even after removal of free agonist. These data are consistent with reports for other GPCR systems that do not desensitize (Calebiro et al., 2009, Fer

• br Materials and methods br Results br Discussion The redox

  2022-04-11

  

  Materials and methods Results Discussion The redox domain that spans the region between amino aurora a receptor positions 35 and 127 of the major human AP endonuclease, APE1, regulates the sequence-specific DNA binding of various transcription factors [[52], [85]]. The existent crystal str

• Introduction The West syndrome or

  2022-04-09

  

  Introduction The West syndrome or epilepsy with epileptic spasms (ES) is an epileptic encephalopathy in early infancy with probable seizure-related developmental regression. According to the United Kingdom Infantile Spams Study (UKISS), common causes of infantile spasms include hypoxic-ischemic enc

• How do myofibroblast sources compare

  2022-04-09

  

  How do myofibroblast sources compare between bone marrow and other organs? Perivascular d-cycloserine with MSC properties significantly contribute to fibrosis in muscle, fat, skin, heart, kidney, lung, and liver (reviewed in Iwayama et al., 2015) and activate Gli1 in many of these organs (Kramann et

14446 records 448/964 page Previous Next First page 上5页 446447448449450 下5页 Last page