• Another mechanism underlying on the toxicity

  2021-08-12

  

  Another mechanism underlying on the toxicity of dopaminergic neurons might be related to dopamine-dependent initial oxidative stress [60]. Dopamine TAK-242 mediated by monoamine oxidase (MAO) can produce hydrogen peroxide as a by-product, and excess dopamine can undergo auto-oxidation to quinones or

• In studies directed toward the development of sequence speci

  2021-08-12

  

  In studies directed toward the development of sequence-specific major-groove binding small MLN 9708 [11], we desired a non-intercalating molecular scaffold that could direct attached moieties into the major groove. As an initial step toward this goal, we wished to study the DNA binding mode and af

• The archaea are a group of microorganisms and

  2021-08-12

  

  The archaea are a group of microorganisms, and many belong to extremophiles, living in extreme environments, such as those with high temperatures [6], [7]. Methanocaldococcus jannaschii is a methane-producing archaea [8]. It grows at pressures of up to more than 200atm and at an optimum temperature

• In conclusion we have recombinantly expressed

  2021-08-12

  

  In conclusion, we have recombinantly expressed and purified the product of the YP_002262821.1 gene from A. salmonicida and confirmed that it possesses ATP-dependent DNA ligase activity. Comparison of the full-length and truncated versions of the protein indicate that the N-terminal 25 MK-4827 Racema

• Introduction BRs are well known class of steroid

  2021-08-12

  

  Introduction BRs are well known class of steroid phytohormones involved in the regulation of key processes of plant growth and development [1], [2], [3], [4], [5]. A lot of attention is driven to BRs in the last decade because of their undeniable functions in promoting GSK461364 reactions of plant

• Sequence alignment of cfALDH with the human ALDH

  2021-08-12

  

  Sequence alignment of cfALDH with the human ALDH1 indicates that the cyanobacterial protein contains the same GQCC motif as the human ALDH1 and ALDH2 proteins [24] (Fig. 1d, highlighted in red, and Supplementary Fig. 2). This motif is present in ALDH1/2 orthologues and these residues reside at the b

• PPY A synthesis Collagen alignment can contribute to tissue

  2021-08-12

  

  Collagen alignment can contribute to tissue stiffening (Malik et al., 2015, Paszek et al., 2005), and ECM stiffness in turn is a powerful activator of integrin function (Levental et al., 2009). These findings highlight the contribution of the mechanical properties of the ECM to signal transduction.

• It is interesting to note that oligomerization

  2021-08-12

  

  It is interesting to note that oligomerization of recombinant DDR1 ECD primarily occurred when the protein was incubated with collagen in solution and to a much lesser extent when collagen was pre-immobilized on a surface as reported in our earlier studies (Agarwal et al., 2007). We believe that pre

• br Funding This work was supported by

  2021-08-12

  

  Funding This work was supported by grants to A.S. from the Swedish Cancer Foundation, Sweden (Grant number: CAN, 2015/637), the Swedish Medical Council, Sweden (Grant number: 2017- 01274), the Foundations at Skåne University Hospital, Sweden and to KB, SRS, NC, BCS, and SS from the Royal Physiogr

• In untreated rodent or human hepatocytes

  2021-08-12

  

  In untreated rodent or human hepatocytes, PXR or CAR is stabilized by cytoplasmic co-chaperone partners like heat shock protein 90 (HSP90, Fig. 1). Upon ligand binding, the nuclear receptors are freed and translocated into the nucleus, identified as a pivotal step in PXR- or CAR-mediated transactiva

• The early serologic response of infants to infection with

  2021-08-12

  

  The early serologic response of infants to infection with HIV-1 is obscured by the presence of transplacentally acquired maternal HIV antibody. However, the HIV 74 produced in vitro by peripheral blood from infants has been studied (Pollack et al., 1993) and it has been shown that neonatal infants

• Compounds and were outliers for

  2021-08-11

  

  Compounds and were outliers for this equation being the two most reactive compounds. The presence of outliers implies that other factors or specific mechanisms are involved in their chemical hydrolysis. Generally urea derivatives prove to be highly stable in aqueous solutions in vitro. Additional

• br Multi hierarchical structure of

  2021-08-11

  

  Multi-hierarchical structure of collagen Protein structure is the foundation of protein functions and properties. It is generally accepted that the protein has biological function only when it has tertiary structure or above. Among the identified 28 types of collagen, most is known about type I c

• We did not observe inhibition of vCPH

  2021-08-11

  

  We did not observe inhibition of vCPH by any of the TCA cycle intermediates (apart from the metal chelators citrate and isocitrate), nor by the factor inhibiting HIF (FIH; a 2OG-dependent asparaginyl hydroxylase) inhibitor N-oxalyl d-phenylalanine (NOF) or the γ-butyrobetaine dioxygenase inhibitor m

• Biochemically the primary function of PPIP

  2021-08-11

  

  Biochemically, the primary function of PPIP5K2 is 1-kinase-mediated phosphorylation of 5-IP7 to form 1,5-IP8 (Shears, 2018). To a lesser extent, PPIP5K2 also phosphorylates IP6 to produce 1-IP7. Furthermore, PPIP5K2 has been shown to catalyze a reverse reaction, that is, dephosphorylation of 1,5-IP8

14112 records 572/941 page Previous Next First page 上5页 571572573574575 下5页 Last page